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⇤ APPLICATIONS, ARTICLES & TECHNICAL NOTES

A time-saving pump validation method for preparative chromatography

A time-saving pump validation method for preparative chromatography


Regular pump flow rate validation is a crucial tool in ensuring pump performance, repeatability, and compliance with regulations. In this investigation, a non-invasive, real time flow monitoring device – the Prep Flowmeter was used to validate a Teledyne SSI M1 40ml single-headed, positive displacement piston pump commonly used for preparative liquid chromatography applications. The Prep Flowmeter has an operating range of 1 – 650 ml/min and is based around a thermal flow sensor, where it can be demonstrated that the difference in temperature measured by the devices two sensors is a function of the flow rate. Using a proprietary algorithm this temperature difference is then converted into absolute flow rate units.